Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 34, Issue -, Pages 535-536Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0340535
Keywords
gene conversion; HapMap; hotspot; human genetic variation; polymorphism; recombination
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Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide variation data provide evidence for a weak fixation bias in favour of G and C alleles that is strongest at the Centre of inferred recombination hotspots.
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