Journal
NATURE NEUROSCIENCE
Volume 9, Issue 8, Pages 993-995Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1742
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Funding
- FIC NIH HHS [1R03 TW05763] Funding Source: Medline
- NINDS NIH HHS [R01 NS41029] Funding Source: Medline
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How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.
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