Journal
GENESIS
Volume 44, Issue 8, Pages 361-363Publisher
WILEY
DOI: 10.1002/dvg.20225
Keywords
Cre; homeobox; hypothalamus; medaka; retina; Rx
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Funding
- NEI NIH HHS [EY12505, EY12163, T32 EY07102] Funding Source: Medline
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Rx is a homeobox-containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5' upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution to a degree that they direct gene expression into the Rx-expressing field of cells in mice. Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina.
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