Journal
ANNALS OF HEMATOLOGY
Volume 88, Issue 10, Pages 947-950Publisher
SPRINGER
DOI: 10.1007/s00277-009-0701-2
Keywords
Thalassemia intermedia; Hemoglobin H disease; MRI
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We performed MRI assessment in 37 adult Chinese patients with thalassemia intermedia and hemoglobin H disease. Despite abnormal ferritin and liver T2*, only 5% of patients had cardiac hemosiderosis. The two patients with reduced ejection fraction had normal cardiac T2*. Half of the cases showed pituitary and pancreatic iron loading. Subclinical endocrine abnormalities (HOMA, insulin growth factor) showed correlation with pancreatic, pituitary, and cardiac MRI values. Prospective data with serial functional and imaging monitoring is needed to verify the utility for chelation to improve cardiac and endocrine function in this group of patients.
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