4.7 Article

Common deactivation patterns during working memory and visual attention tasks: An intra-subject fMRI study at 4 Tesla

Journal

HUMAN BRAIN MAPPING
Volume 27, Issue 8, Pages 694-705

Publisher

WILEY
DOI: 10.1002/hbm.20211

Keywords

visual attention; working memory; fMRI; activation; deactivation; PET; CBF

Funding

  1. NCRR NIH HHS [M01 RR010710, 5-M01-RR-10710, M01 RR010710-06S1] Funding Source: Medline
  2. NIDA NIH HHS [R03 DA017070-01, R03 DA017070, K24 DA16170, K02 DA16991] Funding Source: Medline

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This parametric functional magnetic resonance imaging (fMRI) study investigates the balance of negative and positive fMRI signals in the brain. A set of visual attention (VA) and working memory (WM) tasks with graded levels of difficulty was used to deactivate separate but overlapping networks that include the frontal, temporal, occipital, and limbic lobes; regions commonly associated with auditory and emotional processing. Brain activation (% signal change and volume) was larger for VA tasks than for WM tasks, but deactivation was larger for WM tasks. Load-related increases of blood oxygenation level-dependent (BOLD) responses for different levels of task difficulty cross-correlated strongly in the deactivated network during VA but less so during WM. The variability of the deactivated network across different cognitive tasks supports the hypothesis that global cerebral blood flow vary across different tasks, but not between different levels of task difficulty of the same task. The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network.

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