Journal
EXPERT REVIEW OF VACCINES
Volume 5, Issue 4, Pages 505-516Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.5.4.505
Keywords
cellular-mediated immunity; HIV-1; vaccine
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The definition of immune correlates of protection in HIV-1 infection is pivotal to the design of successful vaccine candidates and strategies. Although significant methodological and conceptual strides have been made in our understanding of HIV-specific cellular immunity we have not yet defined those parameters that have a role in controlling the spread of HIV infection. This review discusses the basis of our understanding of HIV-specific cellular immunity and identifies its shortcomings. Furthermore, potential protective characteristics will be proposed that may ultimately be required for an effective vaccine designed to stimulate cellular immunity against HIV-1.
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