Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 16, Pages 8263-8266Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00400-06
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Funding
- Medical Research Council [G9818340B] Funding Source: researchfish
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Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4(+) T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5-restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells.
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