Journal
EPILEPSIA
Volume 47, Issue 8, Pages 1383-1391Publisher
WILEY
DOI: 10.1111/j.1528-1167.2006.00604.x
Keywords
motor cortex; movement representations; hippocampus; afterdischarge; seizure; epilepsy
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Purpose: To determine whether seizure activity, repeatedly elicited in the hippocampus, could alter the functional organization of neocortical movement representations (motor maps) and whether a relation exists between the number of afterdischarges recorded in the sensorimotor neocortex and the size of the motor maps. Methods: We electrically kindled the right ventral hippocampus of Long-Evans hooded rats, twice daily, for 40 sessions and recorded the afterdischarges in the stimulated hippocampus and right sensorimotor neocortex. Between 3 and 7 days after the last seizure, we used high-resolution intracortical microstimulation to derive the forelimb-movement representations in the left (un-implanted) sensorimotor neocortex. Results: In the hippocampal kindled rats, we observed a dramatic expansion of the area of neocortex that would elicit forelimb movements compared with sham-kindled controls. The number of afterdischarges recorded in the neocortex was significantly and positively correlated with the size of the motor maps. Conclusions: Seizures propagating from the hippocampus have long-distance effects on the functional organization of motor maps.
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