Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 12, Issue 8, Pages 769-775Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2006.01495.x
Keywords
IS6110; isoniazid resistance; katG (Delta 315 mutation); Mycobacterium tuberculosis; public health impact; restriction fragment length polymorphism analysis; The Netherlands
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A previous limited study demonstrated that Mycobacterium tuberculosis isolates with a mutation at amino-acid position 315 of katG (Delta 315) exhibited high-level resistance to isoniazid and were more frequently resistant to streptomycin. In the present study, isoniazid-resistant M. tuberculosis isolates from 8332 patients in The Netherlands (1993-2002) were screened for the Delta 315 mutation. Isoniazid resistance was found in 592 (7%) isolates, of which 323 (55%) carried Delta 315. IS6110 restriction fragment length polymorphism analysis showed that Delta 315 isolates occurred in clusters, suggesting recent transmission, at the same frequency as isoniazid-susceptible isolates. In contrast, other isoniazid-resistant isolates clustered significantly less frequently. Delta 315 isolates were high-level isoniazid-resistant, streptomycin-resistant and multidrug-resistant significantly more often, and may have a greater impact on public health, than other isoniazid-resistant isolates.
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