Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 31, Pages 11567-11572Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0603363103
Keywords
mitochondria; phosphorylation
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Funding
- NCI NIH HHS [R01 CA075503, P30CA56036, R01CA75503, R01 CA093596, R01CA93596, R01 CA070896, R01CA107382, R01CA86072, R01 CA086072, R01 CA107382, P30 CA056036, R01CA70892] Funding Source: Medline
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Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-encoded mitochondrial genes, was repressed in expression and activity by cyclin D1. Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function.
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