Journal
MICROBES AND INFECTION
Volume 8, Issue 9-10, Pages 2409-2413Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2006.05.002
Keywords
mycobacterium; lung; infection; innate; interleukin-1
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Mycobacterium kansasii is an emerging pathogen that is able to induce pulmonary disease resembling tuberculosis. To determine the role of interleukin (IL-)1 in lung infection caused by this atypical mycobacterium, IL-1 receptor type I knockout (IL-1R(1) KO) and normal wild type mice were intranasally infected with M. kansasii. IL-1R(1) KO mice demonstrated a reduced antibacterial response in the lungs and an increased dissemination to the liver, which was accompanied by an enhanced pulmonary inflammatory response. These data identify IL-1 as an important component of the innate immune response to lung infection by M. kansasii. (c) 2006 Elsevier SAS. All rights reserved.
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