Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 80, Issue 2, Pages 237-244Publisher
WILEY
DOI: 10.1189/jlb.0206123
Keywords
PAMP; AMBP-1; septic shock
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Thirteen years after the isolation of adrenomedullin (AM) from a human pheochromocytoma, the literature is awash with reports describing its implication in countless physiological and disease mechanisms ranging from vasodilatation to cancer promotion. A growing body of evidence illustrates AM as a pivotal component in normal physiology and disease with marked beneficial effects in the host defense mechanism. Exogenous administration of AM as well as its ectopic overexpression and the use of drugs, which potentiates its activity, are promising strategies for treatment of septic shock and several other pathogen-related disorders. Although major progress toward this end has been achieved over the past few years, our further understanding of the pleiotropic mechanisms involved with AM as a protective peptide is paramount to maximize its clinical application. J. Leukoc. Biol. 80: 237-244; 2006.
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