Journal
PHYSIOLOGY
Volume 21, Issue -, Pages 250-258Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00008.2006
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Funding
- NHLBI NIH HHS [R01 HL-070070, U01 HL-70525, R01 HL-73167] Funding Source: Medline
- NIDDK NIH HHS [R21 DK-073590] Funding Source: Medline
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Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.
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