Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 17, Issue 4, Pages 259-280Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2006.05.001
Keywords
IL-15; IL-15 receptor alpha; apoptosis; signal transduction; trans-presentation
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The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance. (c) 2006 Elsevier Ltd. All rights reserved.
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