Journal
AUTOIMMUNITY REVIEWS
Volume 5, Issue 7, Pages 465-470Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2006.03.010
Keywords
common variable immunodeficiency; autoimmunity; cytopenia; granulomatous disease; class-switched memory B cells
Categories
Ask authors/readers for more resources
Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by various degrees of hypogammaglobulinemia. Similar to many immunodeficiency disorders, autoimmunity is common with an association with autoimmune cytopenias, a sarcoidosis-like disorder and inflammatory bowel disease. Recent efforts have characterized selective immunological defects and genetic associations in CVID and demonstrate an increased tendency towards loss of tolerance. The mainstay of treatment of automimune disease in such patients is often high dose IVIG and corticosteroids, although other therapies, including TNF-alpha antagonists, have been reported. While the etiology of increased autoimmunity in CVID remains elusive, certain genetic predispositions in combination with repeated antigen exposure and overall immune dysregulation inherent in CVID likely play a significant role. (c) 2006 Elsevier B.V. All fights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available