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The Tishchenko reaction: A classic and practical tool for ester synthesis

Journal

CHEMISTRY LETTERS
Volume 35, Issue 8, Pages 824-829

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2006.824

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This article reviews the Tishchenko reaction: 2 RCHO -> RCOOCH2R (R = hydrogen, alkyl, and aryl), describing the reaction mechanisms, homogeneous and heterogeneous catalysts developed for the reaction, a number of specific examples, and the utility of the reaction in the industrially large-scale production of ethyl acetate from acetaldehyde.

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