Journal
FEBS LETTERS
Volume 580, Issue 18, Pages 4332-4336Publisher
WILEY
DOI: 10.1016/j.febslet.2006.06.091
Keywords
lactoferrin; KDR/Flk-1; VEGF; migration; proliferation
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Lactoferrin (LF) is a multifunctional iron-binding glycoprotein, which plays a variety of biological processes including immunity. In this study, we demonstrate that human LF upregulates KDR/Flk-1 mRNA and protein levels in HUVECs at an optimal concentration of 5 mu g/ml, which subsequently promotes the VEGF-induced proliferation and migration of the endothelial cells. Exposure of HUVECs to LF significantly increased VEGF-induced ERK MAP kinase phosphorylation. The maximal stimulation of KDR/Flk-1 expression by LF was correlated with LF-induced increase in cell proliferation and migration. These findings suggest that LF may stimulate in vivo angiogenesis via upregulation of KDR/Flk-1 expression in endothelial cells. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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