4.4 Article

Phenylboronic acid as a mild and efficient catalyst for Biginelli reaction

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 32, Pages 5697-5699

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.06.015

Keywords

Biginelli; boronic acid; 3,4-dihydropyrimidinone; three-component condensation

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The synthesis of 3,4-dihydropyrimidinone derivatives was achieved in good to excellent yields using phenylboronic acid as catalyst to promote the Biginelli three-component condensation of a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea. (c) 2006 Elsevier Ltd. All rights reserved.

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