Journal
BRITISH JOURNAL OF CANCER
Volume 95, Issue 3, Pages 331-338Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603253
Keywords
cervical adenocarcinoma; human papillomavirus; interphase fluorescence in situ hybridisation; chromosome arm 3q; telomerase; early detection
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The level of genomic amplification of the human telomerase gene TERC, which maps to chromosome band 3q26, was determined in primary cervical adenocarcinomas. Interphase nuclei prepared from archival material of 12 primary cervical adenocarcinomas, eight of which were human papillomavirus positive, were hybridised with a triple colour probe set specific for centromeres of chromosomes 3 and 7 and the TERC gene. We observed high proportions of nuclei with increased absolute copy numbers for TERC in all tumours (mean 3.3; range 2.3-5.2). Amplification of the human telomerase gene TERC is a consistent aberration in cervical adenocarcinomas. Therefore, application of our probe set may provide an objective genetic test for the assessment of glandular cells in Pap smears and hence for the diagnosis of cervical adenocarcinomas.
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