Journal
CANCER LETTERS
Volume 239, Issue 2, Pages 157-167Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.07.029
Keywords
DNA damage; benzo(a)pyrene; immunchistochemistry; DNA repair
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Funding
- NIEHS NIH HHS [R01 ES 011126, R01 ES 011126-S1, R01 ES011126] Funding Source: Medline
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The evidence for polycyclic aromatic hydrocarbons (PAH) playing a role in prostate carcinogenesis comes mainly from associations between reported PAH exposures and prostate cancer in epidemiologic studies. Associations between prostate cancer and DNA repair genotypes and phenotypes have also been reported, lending further credence to a PAH-induced carcinogenesis pathway in prostate cancer. Recent work that demonstrates the human prostate has metabolic enzyme activity necessary for PAH activation and will form DNA adducts upon exposure to PAH further supports PAH carcinogenesis. We have demonstrated the presence of PAH-DNA adducts in prostate cancer cases, but further validation of this biomarker as a carcinogenic agent in human prostate is needed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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