Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 32, Pages 12156-12160Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0605211103
Keywords
plasticity; senescence; visual system
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Funding
- NEI NIH HHS [R01 EY003991, EY03991, P30-EY012576, P30 EY012576] Funding Source: Medline
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The aging nervous system is known to manifest a variety of degenerative and regressive events. Here we report the unexpected growth of dendrites in the retinas of normal old mice. The dendrites of many rod bipolar cells in aging mice were observed to extend well beyond their normal strata within the outer plexiform layer to innervate the outer nuclear layer where they appeared to form contacts with the spherules of rod photoreceptors. Such dendritic sprouting increased with age and was evident at all retinal eccentricities. These results provide evidence of retinal plasticity associated with normal aging.
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