Journal
CANCER LETTERS
Volume 239, Issue 2, Pages 271-280Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.08.025
Keywords
angiogenesis; rosmarinic acid; reactive oxygen species; vascular endothelial growth factor; interleukin-8
Categories
Ask authors/readers for more resources
Rosmarinic acid (RA), a water-soluble polyphenolic compound with anti-oxidative and anti-inflammatory activities, inhibited several important steps of angiogenesis including proliferation, migration, adhesion and tube formation of human umbilical vein endothelial cells (HUVEC) in a concentration-dependent manner. RA also reduced intracellular reactive oxygen species (ROS) level, H2O2-dependent VEGF expression and IL-8 release of endothelial cells. These findings suggested that the anti-angiogenic potential of RA might be related to its anti-oxidative activity, which further resulted in the inhibition of ROS-associated VEGF expression and IL-8 release. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available