Journal
NEUROLOGY
Volume 67, Issue 3, Pages 502-504Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000227961.55640.2f
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Funding
- Wellcome Trust [074454] Funding Source: Medline
- Alzheimers Research UK [ART-PG2003-3] Funding Source: researchfish
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The authors studied seven patients with mitochondrial DNA ( mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications.
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