Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 32, Pages 8278-8288Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1231-06.2006
Keywords
InsP(3) receptor; SERCA; aminergic interneurons; Gq; phospholipase C; flight patterns
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Ionic Ca2+ functions as a second messenger to control several intracellular processes. It also influences intercellular communication. The release of Ca2+ from intracellular stores through the inositol 1,4,5-trisphosphate receptor (InsP(3)R) occurs in both excitable and nonexcitable cells. In Drosophila, InsP(3)R activity is required in aminergic interneurons during pupal development for normal flight behavior. By altering intracellular Ca2+ and InsP(3) levels through genetic means, we now show that signaling through the InsP3R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. Decreased Ca2+ release in aminergic neurons during development of the flight circuit can be compensated by reducing Ca2+ uptake from the cytosol to intracellular stores. However, this mode of increasing intracellular Ca2+ is insufficient for maintenance of flight patterns over time periods necessary for normal flight. Our study suggests that processes such as maintenance of wing posture and formation of the flight circuit require InsP(3) receptor function at a slow timescale and can thus be modulated by altering levels of cytosolic Ca2+ and InsP(3). In contrast, maintenance of flight patterns probably requires fast modulation of Ca2+ levels, in which the intrinsic properties of the InsP(3)R play a pivotal role.
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