Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 171, Issue 2, Pages 355-362Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2006.03.040
Keywords
antipsychotics; gene expression; serotonin receptors; body weight
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This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. (c) 2006 Elsevier B.V. All rights reserved.
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