Journal
TETRAHEDRON
Volume 62, Issue 33, Pages 7838-7845Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.05.049
Keywords
indolocarbazoles; bisindolylmaleimide; Go6976; UCN-01; checkpoint inhibitors
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The syntheses of new nitrile and amide analogues of 7-keto Go6976 are described. The amide analogue 22 was formed via the condensation with a new functionalized indoleacetic acid derivative 25 to overcome the solubility problem during the coupling reaction. (c) 2006 Elsevier Ltd. All rights reserved.
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