Journal
NEUROSCIENCE LETTERS
Volume 404, Issue 1-2, Pages 122-126Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.05.023
Keywords
5-HT7 receptors; SB-269970; hypothermia; ACTH; corticosterone; 8-OH-DPAT
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The physiological function of 5-HT7 receptors is not yet fully determined. This study was designed to characterize the involvement of 5-HT7 receptor in rat body temperature regulation and in adrenocorticotropic hormone (ACTH) and corticosterone secretion. In the first part of our study, acute administration of SB-269970 (0.1-1 mg/kg, i.p.), a potent and selective 5-HT7 receptors antagonist, dose-dependently prevented 5-HT1A/7 receptor agonist 8-OH-DPAT (0.1 mg/kg, s.c.)-induced hypothermia and when the 5-HTIA receptor antagonist WAY-100,635 was co-injected with S13-269970, a reduction of the latter hypothermia was obtained in an additive manner. In contrast, 1 mg/kg (i.p.) of SB-269970 failed to prevent 8-OH-DPAT (0.5 mg/kg, s.c.)-induced increase of ACTH and corticosterone plasma levels. In conclusion, the present results unveil an additive effect of both 5-HTIA and 5-HT7 receptors in core body temperature regulation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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