Journal
EXPERIMENTAL CELL RESEARCH
Volume 312, Issue 14, Pages 2660-2665Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2006.06.011
Keywords
homologous recombination; DNA lesion; DNA replication; translesion DNA synthesis; D-loop; genome integrity; replication restart
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DNA replication is a fragile process, since unavoidable lesions in the template DNA cause replicative polymerases to stall, posing a serious threat to genome integrity. Homologous recombination, translesion DNA synthesis and de novo reinitiation of DNA synthesis ensure robust replication by navigating it passed damaged DNA. In this review, we highlight the relationship between these three processes. (c) 2006 Elsevier Inc. All rights reserved.
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