Journal
GENES & DEVELOPMENT
Volume 20, Issue 16, Pages 2208-2213Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.381906
Keywords
pancreas; spleen; Bapx1(Nkx3.2); metaplasia; cyst
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Funding
- Medical Research Council [MC_U127527180, MC_U127584494] Funding Source: Medline
- Medical Research Council [MC_U127584494, MC_U127527180] Funding Source: researchfish
- MRC [MC_U127584494, MC_U127527180] Funding Source: UKRI
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During early stages of pancreatic development, the mesenchyme that contributes to the spleen overlies the dorsal pancreatic endoderm. Here, we show that interactions between splenic mesenchyme and pancreas proceed via a highly orchestrated morphogenetic program. Disruption of morphogenesis, as occurs in the Bapx1(Nkx3.2)(-/-) embryo, results in transformation of these tissues into well-organized, ectopic gut-like structures. Bapx1 plays a crucial organizing role effecting position and separation of the spleen and pancreas to prevent this metaplastic transformation. Similar transformations occur in organ cultures employing wild-type pancreatic endoderm and spleen mesenchyme, revealing the developmental plasticity of the pancreas and that precise spatial and temporal control of tissue interactions are required for development of both organs.
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