Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 14, Issue 16, Pages 5678-5682Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.04.009
Keywords
4H-1,4-benzothiazines; beta-diketone/beta-ketoesters; 2-aminobenzenethiols
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7-Chloro-5-trifluoromethy1/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included. (c) 2006 Elsevier Ltd. All rights reserved.
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