Journal
CLINICAL CANCER RESEARCH
Volume 12, Issue 16, Pages 4790-4793Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-06-1535
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Endocrine therapy is widely accepted as the most important treatment for all patients with hormone receptor - positive breast cancer. However, despite the positive effect of endocrine therapy on clinical outcome, resistance to these drugs inevitably develops. This article reviews the problem of resistance to hormonal therapy and addresses potential approaches to overcome intrinsic or acquired mechanisms of resistance.
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