Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 112, Issue 3-4, Pages 316-320Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2006.04.002
Keywords
pig; TNF-alpha; IL-1 beta; IL-8; LPS; LPS tolerance; CD14
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LPS tolerance is characterized by a reduced sensitivity to subsequent challenge of LPS. In human and mouse models LPS tolerance is closely associated with marked unbalanced production of leukocyte-derived inflammatory mediators which, when overexpressed, led to septic syndrome and shock. Here we characterized the in vitro induction of LPS tolerance in porcine CD14+ spleen cells in order to give insights into LPS tolerance in pigs. Following LPS stimulation, TNF-alpha and, to a minor extent, IL-8 production showed a significant reduction in CD14+ spleen monocytes that were pretreated with LPS in comparison to naive cells, while IL-1 beta production was slightly influenced by LPS stimulation and it was not affected by subsequent LPS challenge. Our findings showed that porcine CD14+ cells undergo a process, which resembles LPS tolerance, providing evidence that swine represent a valuable and useful model to perform experiments to study LPS tolerance and its biological significance. (c) 2006 Elsevier B.V. All rights reserved.
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