Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 14, Issue 16, Pages 5503-5509Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.04.041
Keywords
anti-trypanosomal activity; quinoxaline N-1,N-4-dioxide; vanadium; N,O ligands
Ask authors/readers for more resources
New vanadium complexes of the type [(VO)-O-IV(L)(2)], where L are 3-aminoquinoxaline-2-carbonitrile N-1,N-4-dioxide derivatives, were prepared as an effort to obtain new anti-trypanosomal agents improving the bioactivity of the free ligands. Complexation to vanadium of the quinoxaline ligands leads to excellent antiprotozoal activity, similar to that of the reference drugs nifurtimox and benznidazole and in all cases higher than that of the corresponding free ligands. In addition, it is for the first time that-the V((IV))O-quinoxaline complexes are reported as a family of anti-Trypanosoma cruzi agents. Finally, the anti-trypanosomal activity of these vanadium complexes could be explained on the basis of their lipophilicity and the electronic characteristics of the quinoxaline substituents. (c) 2006 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available