Journal
ANNALS OF EPIDEMIOLOGY
Volume 24, Issue 1, Pages 44-49Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2013.10.003
Keywords
Brassicaceae; China; Colorectal neoplasms; Glutathione S-transferase M1; Glutathione S-transferase T1; Men
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Funding
- National Institutes of Health [R01 CA082729]
- Vanderbilt Clinical and Translational Science Award from the National Center for Research Resources [UL1 RR024975-01]
- National Center for Advancing Translational Sciences [UL1 TR000445-06]
- Fogarty International Clinical Research Scholars and Fellows Program at Vanderbilt University [R24 TW007988]
- Cancer Prevention and Control Training Program at the University of Alabama at Birmingham funded through the National Institutes of Health [5R25 CA047888]
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Purpose: To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms, and colorectal cancer (CRC) in a population of Chinese men. Methods: Using incidence density sampling, CRC cases (N = 340) diagnosed before December 31, 2010 within the Shanghai Men's Health Study were matched to noncases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate levels from spot urine samples. GSTM1 and GSTT1 were categorized as null (0 copies) versus non-null (1 or 2 copies). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between CV intake and GST gene variants with CRC, and statistical interactions were evaluated. Results: CRC risk was not associated with CV intake, whether measured by self-report or by urinary isothiocyanate nor with GST gene variants. No statistical interactions were detected between CV intake and GST gene variants on the odds of CRC. Stratifying by timing of urine sample collection and excluding CRC cases diagnosed in the first 2 years did not materially alter the results. Conclusions: This study provides no evidence supporting the involvement of CV intake in the development of CRC in Chinese men. (C) 2014 Elsevier Inc. All rights reserved.
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