Journal
ORGANIC LETTERS
Volume 8, Issue 17, Pages 3623-3626Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol060783e
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Funding
- NCI NIH HHS [P50 CA103175, R21 CA112216] Funding Source: Medline
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Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.
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