Journal
ORGANIC LETTERS
Volume 8, Issue 17, Pages 3773-3775Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0613665
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Bifunctional macrocycle 1 with C-2 symmetry was newly synthesized. NMR studies demonstrated that receptor 1 functions as a chiral shift reagent (solvating agent) that is highly effective for a wide range of chiral compounds having a carboxylic acid, oxazolidinone, lactone, alcohol, sulfoxide, sulfoximine, isocyanate, or epoxide functionality. Binding constants were determined to investigate the binding behavior of 1.
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