Journal
ORGANIC LETTERS
Volume 8, Issue 17, Pages 3805-3808Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol061481f
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A novel one-pot synthesis of N-difluoromethyl-2-pyridones is described. N-(Pyridin-2-yl) acetamide derivatives were excellent precursors for the preparation of N- difluoromethyl-2-pyridone derivatives. Difluoromethylation of 2-acetaminopyridine derivatives was achieved with sodium chlorodifluoroacetate as a difluorocarbene source in the presence of a catalytic amount of 18-crown-6. Subsequent in situ hydrolysis of resultant 1,2-dihydro-2-acetimino-1-difluoromethylpyridines proceeded under mild acidic conditions to afford the corresponding N-difluoromethyl-2-pyridones in moderate to good yields.
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