Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 17, Pages 6678-6681Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo061043m
Keywords
-
Categories
Ask authors/readers for more resources
A regiocontrolled synthesis of 3,4-disubstituted pyrrole-2carboxaldehydes was completed in two steps from acyclic starting materials. A Barton-Zard pyrrole synthesis between N-methoxy-N-methyl-2-isocyanoacetamide and R-nitroalkenes or,-nitroacetates provided N-methoxy-N-methyl pyrrole-2-carboxamides ( pyrrole Weinreb amides), which were converted into the corresponding pyrrole-2-carboxaldehydes by treatment with lithium aluminum hydride. A regioselective oxidation of the pyrrole-2-carboxaldehydes gave the corresponding 3,4-disubstituted 3-pyrrolin-2-ones.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available