Journal
FEBS LETTERS
Volume 580, Issue 19, Pages 4691-4696Publisher
WILEY
DOI: 10.1016/j.febslet.2006.07.047
Keywords
protein phosphatase 2C; abscisic acid; dominant mutation; hypermorphic
Funding
- NIGMS NIH HHS [R01GM060396] Funding Source: Medline
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Protein phosphatases of the 2C family (PP2C) function in the regulation of several signaling pathways from prokaryotes to eukaryotes. In Arabidopsis thaliana, the HAB1 PP2C is a negative regulator of the stress hormone abscisic acid (ABA) signaling. Here, we show that plants expressing a mutant form of HAB1 in which Gly246 was mutated to Asp (G246D) display strong ABA insensitive phenotypes. Our results indicate that the G246D mutation has a hypermorphic rather than a dominant negative effect. The data suggest that this mutation localized in a conserved motif in the PP2C catalytic domain could be used in other PP2Cs to reveal their biological functions. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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