Journal
FEBS LETTERS
Volume 580, Issue 19, Pages 4607-4612Publisher
WILEY
DOI: 10.1016/j.febslet.2006.07.035
Keywords
sphingosine kinase; sphingolipids; inflammation; arthritis
Funding
- NHLBI NIH HHS [HL67330, HL70694] Funding Source: Medline
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Sphingosine-1-phosophate, generated from the phosphorylation of sphingosine by sphingosine kinase enzymes, is suggested to function as an intracellular second messenger for inflammatory mediators, including formyl peptide, C5a, and Fc. More recently, a role for sphingosine kinases during inflammation has also been proposed. Here we show that sphingosine kinase 1 knockout mice exhibit normal inflammatory cell recruitment during thioglycollate-induced peritonitis and that sphingosine kinase 1-null neutrophils respond normally to formyl peptide. In the collagen-induced arthritis model of rheumatoid arthritis, sphingosine kinase 1 knockout mice developed arthritis with normal incidence and severity. Our findings show that sphingosine kinase 1 is dispensable for inflammatory responses and support the need for more extensive studies of sphingosine kinases in inflammation. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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