Journal
ANNALS OF EPIDEMIOLOGY
Volume 23, Issue 9, Pages 564-570Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2013.07.003
Keywords
Calcium; Vitamin D; Lipids; Blood pressure; Carotenoids
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Funding
- National Institutes of Health [R01CA104637, R03CA132149]
- Georgia Cancer Coalition Distinguished Scholar award
- [R25CA90956]
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Purpose: To estimate the effects of calcium or vitamin D supplementation or a combination of both on blood pressure and serum lipid and carotenoid levels. Methods: Ninety-two colorectal adenoma patients were randomized in a pilot, double-blind, placebo-controlled clinical trial of supplemental vitamin D-3 800 IU and elemental calcium 2.0 g (as calcium carbonate) alone or in combination in divided doses twice daily with meals over 6 months. Results: Relative to placebo, mean serum triglycerides decreased 30% (P = .10) and 32% (P = .10) in the calcium and calcium plus vitamin D-3 treatment groups, respectively. When the two calcium intervention groups were pooled and compared with the pooled noncalcium groups, the estimated supplemental calcium treatment effects were statistically significant for triglycerides (P = .04). Similar but nonstatistically significant decreases (5%-7%) were observed for serum total cholesterol levels. Mean systolic blood pressure increased 6% (P = .08) in the calcium group; otherwise, there were no appreciable changes in systolic or diastolic blood pressures in any active treatment group. Mean serum total carotenoid levels decreased 14% (P = .07) in the calcium and 9% (P = .10) in the calcium plus vitamin D-3 groups. Conclusions: Our results suggest that supplemental calcium alone or combined with vitamin D-3 but not vitamin D-3 alone may reduce serum lipids and lipophilic micronutrients. (c) 2013 Elsevier Inc. All rights reserved.
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