Journal
JOURNAL OF CELL BIOLOGY
Volume 174, Issue 5, Pages 615-623Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200605036
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Funding
- NHLBI NIH HHS [R01-HL67256, R01 HL061897, R01-HL61897, R01 HL067256] Funding Source: Medline
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Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway speci. city to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.
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