Journal
CANCER LETTERS
Volume 240, Issue 2, Pages 183-194Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.08.018
Keywords
KAI1/CD82; tetraspanin; integrin; cell migration; tumor invasion; tumor metastasis
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Funding
- NCI NIH HHS [CA 96991] Funding Source: Medline
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Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these motility-related proteins to inhibit cell migration. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NF kappa B, p53, and beta-catenin. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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