4.4 Article

Friedel-Crafts alkylation of indoles with epoxides catalyzed by nanocrystalline titanium(IV) oxide

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 35, Pages 6213-6216

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.06.163

Keywords

nano TiO2; epoxide; indole; heterogeneous catalyst

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Friedel-Crafts alkylation of indoles with epoxides to afford 3-alkyl indole derivatives at room temperature with moderate to good yields and high regioselectivity using nanocrystalline titanium(IV) oxide catalyst is described. (c) 2006 Elsevier Ltd. All rights reserved.

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