4.4 Article

The first total synthesis and structural determination of lagunamycin

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 35, Pages 6183-6186

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.06.158

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Lagunamycin (1) has been synthesized by using our developed remote stereoinduction, Knorr condensation, periodinane oxidation, and diazonation. This enantioselective synthesis determined the absolute configuration of lagunamycin. Existence of rotational conformers was confirmed by NMR studies. (c) 2006 Elsevier Ltd. All rights reserved.

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