Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 35, Pages 13121-13125Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0605735103
Keywords
comparative genomics; conservation; correlations; noncoding; scaling
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Funding
- NHGRI NIH HHS [1 U01 HG003273, U54 HG003273] Funding Source: Medline
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A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional noncoding sequence and ought to be accounted for in estimating the statistical significance of apparent sequence conservation. These inter-genomic correlations of conservation are placed in the context of previously observed intra-genomic correlations, and their possible origins and consequences are discussed.
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