Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 35, Pages 13198-13202Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0603512103
Keywords
ischemia; stem cells; penumbra; infarct; vascular niche
Categories
Funding
- NIA NIH HHS [R01 AG021980, AG21980] Funding Source: Medline
- NINDS NIH HHS [R01 NS044921, NS44921] Funding Source: Medline
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Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.
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