Journal
ORGANIC LETTERS
Volume 8, Issue 18, Pages 4063-4065Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol061552a
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- NIGMS NIH HHS [GM 61591] Funding Source: Medline
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In this communication, we report an efficient asymmetric Friedel-Crafts reaction that, unprecedently, is applicable to a wide range of both indoles and carbonyls. The use of a readily accessible catalyst in combination with a high enantioselectivity that is insensitive to reaction concentration, temperature, air, and moisture should allow this reaction to provide useful enantioselective access to new chiral indole derivatives.
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