Journal
ORGANIC LETTERS
Volume 8, Issue 18, Pages 4121-4124Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0616790
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A combination of copper chloride, triethyl phosphite, and tetrabutylammonium iodide is a very efficient catalytic system for the synthesis of polyfunctionalized diarylmethanes, using the cross-coupling reaction of arylmagnesium halides with benzylic phosphates. The antibiotic Trimethoprim has been prepared using this Cu(I)-catalyzed cross-coupling in 52% overall yield (four steps).
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