Journal
ORGANIC LETTERS
Volume 8, Issue 18, Pages 3927-3930Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol061308j
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A new palladium-catalyzed synthesis of 3-amido-substituted beta-lactams is reported. This process involves the one- pot coupling of four components, imines, carbon monoxide, and acid chloride, providing a flexible route to construct this class of heterocycle. The generation of beta-lactams with two different imines can also be accomplished, providing a method to assemble these products with independent control over five separate substituents.
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